In an in vivo study in the diabetic model has clearly shown that the administration of pterostilbene (10 to 40 mg/kg body weight) was effective in ameliorating the increased blood glucose levels and in protection from further diabetic complications for 5 weeks. The results showed improvement in the blood glucose level, antioxidant status, and skeletal muscle morphological structure compared to the control group. The researchers strongly suggest the therapeutic potential of pterostilbene in the management of healthy blood sugar levels.
Tastekin B, Pelit A, Polat S et al. Therapeutic potential of pterostilbene and resveratrol on biomechanic, biochemical, and histological parameters in streptozotocin-induced diabetic Rats. Evid Based Complement Alternat Med. 2018;9012352.
Another research study evaluated the efficacy and mechanism of action of pterostilbene in managing the blood glucose in the diabetic condition. The outcome of the study revealed that the administration of the pterostilbene resulted in greater activation of the insulin signalling cascade, increased cardiotrophin-1 levels, liver glucokinase, and glucose-6-phosphatase activities, and reduced activity of fructose-1,6-biphosphatase.
The overall result was improved blood glucose levels. Also, the administration resulted in an improvement in the blood lipid profile.
Elango B, Dornadula S, Paulmurugan R et al. Pterostilbene ameliorates streptozotocin-induced diabetes through enhancing antioxidant signaling pathways mediated by Nrf2. Chem Res Toxicol. 2016;19;29(1):47–57.